Chemical factors such as hydrogen atoms, serotonin, bradykinin, and prostaglandins found in the body stimulate pain receptors and cause pain. These chemical factors play a major role in conditions such as rheumatism, inflammation, bone cancer, and hardening of the heart muscle.
In arthritis, the pain-sensing factors work together to
increase the impact of pain. The chemical factor bradykinin increases the
production of fatty acids called prostaglandins, further increasing the impact
of pain and inflammation.
Pain is also caused by certain vascular substances and
minerals that are produced when tissue is damaged. For example, after physical
exercise, pain persists in the hands, meaning that the pain remains until there
is a slight change in blood flow, and it returns to a normal state. It has been
found that the reason for this pain is the mineral potassium released in muscle
cells.
In cases of heart muscle damage or inflammation, potassium
mineral accumulates due to muscle damage. Here, it acts as a factor that
stimulates pain receptors. In this state, potassium is released, which causes
pain sensation, but the damage caused by this is very small.
Pain sensation increases when there is a change in the
acidity of the fluid of the tissues in the human body. Pain sensation occurs
when the fluid acidity level is pH 6.2, and when the acidity level increases to
pH 3.2, pain increases. The reason for this is hydrogen ions.
Histamine is an amine that causes pain in the upper surface
of the skin and in the intestinal tract. Serotonin is a chemical that acts on
the blood vessels and causes pain caused by migraines and blood vessels.
Painkillers block the production and action of chemical
factors that cause pain and relieve the pain caused by it.